FDA Updates – Warnings For Fluoroquinolone

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Fluoroquinolones have fluoride as a central part of the drug.
Fluoride is a known neurotoxin, and drugs with an attached
fluoride can penetrate into very sensitive tissues.  



Among the most well known is Cipro (made by Bayer), which

became a household name during the anthrax scare

that occurred shortly after 9/11.

Levaquin is a close second.

All antibiotics carry a risk of side effects, but the fluoroquinolones are in a class by
themselves when it comes to their potential to cause serious, permanent injuries and even death.

Given their potential to harm, they should be reserved for treating only the most serious bacterial infections that won’t respond to any other treatment; instead, they’re often offered for mild conditions like sinus, urinary tract and ear infections.

                          Fluoroquinolones: The Deadliest Antibiotics On The Market

If your doctor hands you a prescription for a fluoroquinolone antibiotic
(this could be not only Cipro or Levaquin but also Avelox or generics
ciprofloxacin, levofloxacin, and moxifloxacin, or others),
be very certain that your condition warrants the risks
that come along with taking these drugs.

Fluoroquinolones have fluoride as a central part of the drug.
Fluoride is a known neurotoxin, and drugs with an attached
fluoride can penetrate into very sensitive tissues. 

The fluoroquinolones have the unique ability to penetrate your blood-brain barrier, entering your brain and damaging your central nervous system.
Many of these drugs have already been removed from the market due to their toxicity, and those that remain are riddled with black box warnings required by the U.S. Food and Drug Administration (FDA).

In 2008, the FDA required seven fluoroquinolone antibiotics to add a black-box warning because they pose a risk of tendinitis and increase the risk of a tendon rupture by three to four times. 

But this is far from the only risk. Levaquin, for instance, which was the best-selling antibiotic in 2010, faces thousands of lawsuits a year from people who have been seriously harmed after taking it.1 The reactions can be body-wide, impacting your central nervous system, musculoskeletal, visual and renal systems, sometimes simultaneously. Among the serious reactions reported are

In a 2001 study by Dr. Jay Cohen, the following reaction rates were documented: 2

  • Nervous system symptoms occurred in 91 percent of patients (pain, tingling and numbness, dizziness, malaise, weakness, headaches, anxiety and panic, loss of memory, psychosis)

  • Musculoskeletal symptoms in 73 percent of patients (tendon ruptures, tendonitis, weakness, joint swelling)

  • Sensory symptoms in 42 percent of patients (tinnitus, altered visual, olfactory, and auditory function)

  • Cardiovascular symptoms in 36 percent of patients (tachycardia, shortness of breath, chest pain, palpitations)

  • Skin reactions in 29 percent of patients (rashes, hair loss, sweating, intolerance to heat or cold)

  • Gastrointestinal symptoms in 18 percent of patients (nausea, vomiting, diarrhea, abdominal pain)

In a letter to his Congressman, he wrote:

“These severe reactions are occurring in patients who are usually healthy, active, and young. Most often, the antibiotics are prescribed for mild infections such as sinusitis, urinary or prostate infections. Most reactions occur very quickly, sometimes with just a few doses of the fluoroquinolone antibiotic. Reactions are acute, severe, frightening, and often disabling.

Since the publication of my article with its 45 cases two and a half years ago, I have received e-mails from more than 100 people seeking help for their reactions. In most cases, their doctors have dismissed their complaints or outright denied that the reactions could occur with fluoroquinolones. Yet extensive medical workups do not find any other cause. Worse, there are no known effective treatments. Thus, these people suffer pain and disability for weeks, months, and years.“

Increased Antibiotic-Resistant Infection Rates

Also Linked to Fluoroquinolones

Overuse of these potent antibiotics has been linked to antibiotic resistant infections like methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and the potentially life-threatening diarrhea caused by Clostridium difficile (C. diff). According to some research, being given fluoroquinolones is the most important risk factor in developing Clostridium difficile–associated-diarrhea (CDAD). 3

Again, a large part of the problem is that these drugs, which are meant to be reserved for life-threatening infections that cannot otherwise be treated, are being vastly overused. In a study in BMC Infectious Diseases, it was found that nearly 40 percent of fluoroquinolone treatments at one medical center were unnecessary, while other research found 81 percent of fluoroquinolone prescriptions in two academic emergency departments were inappropriate based on institutional guidelines.4 As reported by The New York Times: 5

“In an interview, Mahyar Etminan, a pharmacological epidemiologist at the University of British Columbia, said the drugs were overused “by lazy doctors who are trying to kill a fly with an automatic weapon.”

The drugs are thought to be particularly dangerous for children under age 18, adults over 60, and pregnant and nursing women, as well as people with liver disease or those taking corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs). But, they are often prescribed for these groups, anyway.

Writing in Forbes, contributor Melanie Haiken recalled taking her teenage daughter to the doctor and being handed a prescription for Cipro for her, even though she was under 18 and seeking treatment for an ear infection… 6 This prompted Haiken to dig deeper before giving her daughter the drug, but many others are completely unaware that the antibiotic they’ve just been prescribed has been linked to such deadly side effects. They assume it’s like any other antibiotic…

Avoid Cipro and Other Fluoride Antibiotics or Run the Risk of SERIOUS Side Effects

If your doctor prescribes you one of these dangerous antibiotics ask him or her to use another one. It is uncommon that this would be the only one that could be used. These dangerous antibiotics should be used as a last resort only. If you do wind up using them then read the package insert and all the warnings VERY carefully and stop them the moment you notice a side effect.

In today’s expansive age of online networking, there exists a large community of people who’ve experienced fluoroquinolone injuries. They often refer to themselves as the “Floxies,” and their numbers continue to grow as the prescriptions flow.

Quite a few of these Floxies are in the medical field themselves (or were, before they were poisoned), and are on a mission to help fellow fluoroquinolone victims. You, too, can help to get the word out by sharing this information with your friends and family, and advising them to consider alternatives before taking these drugs – especially if they’re prescribed for a minor condition.

You wouldn’t knowingly risk permanent blindness, personality changes or psychotic reactions to treat your ear infection, especially if there were a safer alternative… and there nearly always is. David A. Flockhart, professor of medicine and chief of clinical pharmacology at Indiana University School of Medicine, reports as many as one-third of patients taking a fluoroquinolone will experience some sort of negative psychiatric effect, such as anxiety, personality changes, or confusion. He has treated more than 100 patients with such psychiatric side effects, stating:

“The psychiatric effects of the fluoroquinolones are underappreciated by the medical profession as well as by the public. The bigger the gun you use, the more damage you can expect as collateral.”

Cipro, Levaquin and the related drugs in the class are very “big guns”

that should only be used in very special circumstances.

Please be absolutely sure yours is [not] one of

them before consenting to use these drugs.

 A ) Please do your own research on these Fluoride containing drugs

B) Petition to Require a Warning on All Fluoroquinolone Antibiotics

C) More on fluorinated medications

D) FDA updates warnings for oral and injectable 
fluoroquinolone antibiotics due to disabling side effects

Fluoroquinolones have never been registered for use in food
 animals in Australia and must never
be used for that
 purpose while
their use is prohibited.





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“People with kidney impairment have a
lower margin of safety for fluoride intake.
Limited data indicates that their fluoride
retention may be up to three times normal”


Fluoride Is A Developmental Nephrotoxin –
Coming To A Kidney Near You

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image of kidney

People With Kidney Impairment Are At Greater Risk From Fluorides.

Indigenous Australians have smaller kidneys than non-indigenous Australians –

a reduced number of nephrons and decreased renal reserve –

(Singh G, White A, Spencer J, Wang Z, Hoy W [1999]).

Indigenous Australians are 6 times more likely than other Australians to be receiving dialysis or to have had a kidney transplant. Death rates from chronic kidney disease are 7 and 11 times as high for non-indigenous males and females respectively.

Australia’s peak medical advisory body, the Australian Government’s National Health & Medical Research Council (NHMRC) advised in their Australian Drinking Water Guidelines 2004 that:

“People with kidney impairment have a lower margin of safety for fluoride intake.
Limited data indicates that their fluoride retention may be up to three times normal.”

Indigenous Australians have high rates of kidney disease and also diabetes, (6 times higher than for non-Aboriginal Australians) which can lead to kidney disease, they are less able to cope with fluoridation, they will have higher plasma fluoride levels, and circulating for longer will accumulate more fluoride in their bodies (particularly bones) because of their decreased ability to excrete fluoride.


The Queensland Government’s proposal to fluoridate indigenous communities, some of which are currently using underground water of untested levels of existing natural fluoride, can be described as reckless stupidity – genocidal, and needs to be reversed immediately.

Inorganic fluoride. Divergent effects on human proximal tubular cell viability. R. A. Zager and M. Iwata. Fred Hutchinson Cancer Research Center, Seattle, WA …

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Inorganic fluoride. Divergent effects on human proximal tubular cell …

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Fluoride, Cadmium, Arsenic – Chronic Renal Failure/Sri Lanka

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“The 1981 NKF position paper on fluoridation is outdated.
The paper is withdrawn and will no longer be circulated,
effective from the 10/06/07″ – NKF Board of Director’s meeting.


      The safety margin for exposure to fluoride by renal patients is unknown, measurements of fluoride levels are not routine, the onset of skeletal fluorosis is slow and insidious, clinical symptoms of this skeletal disorder are vague, progression of renal functional decline is multifactorial and physicians are unaware of side effects of fluoride on kidneys or bone. 

The Nephrology Dialysis Transplantation is a monthly peer-reviewed medical journal. It is published by Oxford on behalf of the European Renal Association (ERA) and European Dialysis and Transplantation Association (EDTA). It is abstracted and indexed in PubMed/MEDLINE/Index Medicus. According to the Journal Citation Reports, the journal has a 2011 impact factor of 3.564.[1] The journal’s current editor-in-chief is Carmine Zoccali from Italy.

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Fluoride In Drinking Water & Diet: The Causative Factor Of
Chronic Kidney Diseases In The North Central Province of Sri Lanka


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Water Fluoridation Targets Black Americans

Posted by admin on Wednesday, 12 May 2010


Silicofluorides and Higher Blood Lead


At present, U.S. public water systems serving over 140 million people are fluoridated with 200,000 tons of commercial grade hydrofluosilicic acid (H2SiF6) and sodium silicofluoride (Na2SiF6), together called “silicofluorides” (or “SiFs”).

Data from numerous studies show that, taking economic, social and racial factors into account, where silicofluorides are used, children absorb more lead from the environment, and there are higher rates of diseases and behavioral problems associated with lead poisoning (including hyperactivity, substance abuse, and violent crime).

Although some early studies showed differences between sodium fluoride and sodium silicofluoride, to this day the substitution of silicofluorides in public water treatment facilities HAS NEVER BEEN SUBJECTED TO APPROPRIATE ANIMAL OR HUMAN TESTING. Recently, the Assistant Administrator of the EPA admitted to Congress that his agency had no data on SiF toxicity and the Chief of the Treatment Technology Evaluation Branch at the National Risk Management Research Laboratory confirmed that the EPA has “no” data on the “health and behavioral effects of fluosilicic acid.”

Despite claims of safety by oral health officials, laboratory research in Germany revealed that silicofluorides do not dissociate completely and have important biological effects. To follow up on this issue, we have compared children’s blood lead levels in communities using SiF treated water with communities using sodium fluoride or with non-fluoridated water. In three separate samples, totaling over 400,000 children, SiF treated municipal water is ALWAYS significantly associated with increased blood lead levels in children.

This effect was evident in a Massachusetts survey of lead levels in 280,000 children (see graph for children exposed to SiF from the Greater Boston water system, from towns that add SiF locally, or from communities using sodium fluoride, and towns without fluoridation). For the state of New York, data was available on venous blood lead levels for 151,225 children in communities of 15,000 to 75,000. Controlling for other factors associated with higher blood lead, silicofluorides were again significantly associated with higher uptake of lead from the environment. For black children, who are especially at risk for high blood lead, those in towns using SiF were less likely to have low blood lead and more likely to have lead over 10µg/dL. To confirm that these results are not due to other socio-economic or demographic factors, additional statistical tests were run.

The third study concerned children’s blood lead levels in the National Health and Nutrition Evaluation Survey (NHANES III), which had reports for 7224 children from 80 counties with populations over 500,000. Since only 4 of these counties had any communities that used sodium fluoride, analysis of the NHANES III data focused on the percentage of the entire county population exposed to silicofluoride treated water.

Among the 1543 children of all ages from large urban counties with over 80% of the population exposed to fluoridation (almost all of whom receive water treated with SiF), average blood lead was 5.12 µg/dL whereas the average for 1139 children in low fluoride exposure counties was 3.64 µg/dL Blood lead in the 473 children sampled from the medium fluoridation counties was 3.23 µg/dL, which was significantly different from the high fluoridation counties but not from either low fluoridation counties or those with unknown fluoridation status, where average blood lead levels were 3.16 µg/dL (S.D. 2.83). Controlling for the Poverty, the effect of SiF use was highly significant (p < .0001). When the sample is divided by age and race, these findings provide six separate samples in which SiF is associated with high blood lead (see Graphs).

In all three populations studied, those children in each racial category and each age group who were highly likely to be exposed to silicofluorides differ strongly in levels of blood lead from those not exposed.

This conclusion was further checked by analyzing available data for health and behavioral traits that have been associated with high blood lead (such as violent crimes, cocaine use and asthma). In each case, those exposed to silicofluoride treated water were more likely to have behavioral or health problems that are more likely among those with high lead in their bodies.

The injection of silicofluorides in public water supplies is a practice whose elimination could possibly contribute to reduced rates of learning disabilities, substance abuse, violent crime, and asthma (all connected with lead poisoning and other toxins). Whatever the benefits to teeth (and this is highly controversial), our research shows that the issues facing the public concern silicofluoride chemistry, toxicology, and the linkage of neurotoxins with behavior or health. Before SiF chemicals are used, citizens must know that they are safe for all.


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People Are Drinking More Bottled Water

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